After decades of doubt about the nature of the disease that caused the Black Death, the identification in 2011 of Yersinia pestis in a 14th-century London cemetery – and, most importantly, the revelation of its genetic proximity to current forms of the bacterium – closed that (sometimes harsh) debate, and demonstrated beyond all doubt the main role of paleogenomics in the future studies of historical epidemics, especially plague. However, the role of historians has not diminished with the arrival of this new protagonist in the field of disease history. On the contrary, the need for on-going multidisciplinary dialogue has become undeniable and mandatory, if the ultimate goal is effectively to advance knowledge about historical epidemic phenomena…